On the map Cygnus, which is used in ranked multiplayer, the starting positions are not even. In this case, I am specifically referring to the difficulty of initial expansion. From the upper right starting position, it is easy (~5 seconds to spare) to cap both a radioactive and a metal region prior to creeps appearing. From the lower left starting position, I honestly believed it was not possible until my opponent managed to do so in a match last night.
With the recent adjustments to creep strength, along with the archer nerf some time ago, failing to accomplish the initial double-expansion puts you at a significant disadvantage.