Still a noob and playing at "easiest possible unless you want the Substrate to just surrender at the beginning".
When I win in the SP skirmishes, there's a "Keep on playing" option. But in Campaign there isn't. I *always* want that option because (1) I really enjoy kicking ash when I finally get to do it and (2) It's a great opportunity to experiment with and learn about units and capabilities.
So I would say, even if the enemy Nexus is gone and I have all the Turinium, let me keep playing.
Thanks