With focuses, specialization still wins.
Let's do some numbers. In all cases, 3 planets with 100 production and 900% bonuses. Also, the results aren't totally accurate, as there's 1% unaccounted for on the 33/33/33 global wheel, but they give a good enough indication.
Set 1: 1 econ specialized, 1 manu, 1 research, global wheel set to 33/33/33
Each planet produces 580 of it's focused resource, and 21 of it's other resources, for a total output of 622 per planet or 1866 total.
Set 2: same setup, but each planet has a 300% bonus to each.
Each world produces 232 of it's focused resource, and 84 for each of it's non-focused resources, for a total of 400/planet or 1200 total - a massive reduction.
Set 3: same setup as example 1, but with 50/50 research manu on the global wheel.
The research and Manu planets now each produce 750 of their main resource and 25 of one off resource, and the Econ world produces 250 econ and 38 each of manu/research. Total output is 775 for two planets and 325 for the third, for a total of 1876 (the 10 extra here is that 1% I mentioned earlier) - the same as #1.
Set #4: Same setup as Set 3, but planets have 300% bonus to each production type.
Research and manu planets produce 300/100/0. Econ planet produces 152/100/152. Grand total is 1204 (again, the slight difference from set 2 here is from the missing 1%)
These all assume an even split between the three world, though. Set 3, if we ditch change the Econ world to a Research of Industry planet, becomes much more powerful than set 1. But they still remain much better specialized than split, as we can see from the difference between set 3 and set 4.
Specialization remains king.