Money is best invested, not hoarded.
The black market is a powerful tool, use it early and often.
Use [Tab] to keep an eye on your opponents.
Take care when upgrading. You will be more vulnerable when low on money.
Secure Upgrade resources early. They will allow you to expand your corporation.
The Offworld Market is a great tool to finish games when prices have fallen low.
The Patent Lab offers unique abilities to your corporation, but only one player can have each patent. Acquire patents early if you think you need them.
Purchasing your own stock will make it far more difficult for competitors to acquire your company.
The neutral colony consumes a lot of resources, and changes every game. Check up on it occasionally.
Neutral colony buildings each offer a unique benefit. Try to use them to enhance your corporation.
The map is different every game. Identify scarce resources, and attempt to secure them before your competitors.
Each company type is unique. If you're struggling with one, don't be afraid to try the others.