Don't know much about what is possible for mods, but as for the rest:
One attack type is best, because that way you only have to break through one of the targets defences.
Kinetics in my experience, as long as you do something to boost the range and accuracy of your kinetic weapons.
The biggest reason you'd want to use a different weapon type is to avoid the best defence type of the opposing fleet. Other than that kinetic weapons will do the least overkill, so if you're up against fighters they're probably the best, but practically speaking the biggest consideration after opposing defence is maintenance cost. Beam maint >>> kinetic > missile.
Edit: I should also mention that the initial build cost is kinetic > beam > missile, but I don't think it's hugely important.
Black holes are space terrain and where antimatter spawns.