I am experiencing two graphics issues in DX 12 (high graphics settings):
1) The lower right hand side of my screen has a box about the height of the UI in which half the pixels are fuzzy/gray and half are normal (sort of like the white noise image on an old TV).
2) Some Substrate models, particularly larger ones, are experiencing glitches in their artwork.
I did not have this problem in DX11.
Just did a clean reinstall of my graphics card and newest drivers/software from AMD released in March.